Association of GRO-α in the genesis of malignant melanoma

恶性黑色素瘤是一种预后不良的皮肤肿瘤，它经常复发和转移。因此，了解其发生发展的机制具有重要意义。我们研究了可能在黑色素形成和肿瘤发生中起一定作用的几个因素的关联，并与其他色素皮肤疾病和肿瘤进行了比较。在老年性黄斑的情况下，角质细胞衍生的内皮素1被证明与黑色素生成有关。皮肤纤维瘤上覆表皮的色素沉着是通过上调干细胞因子和肝细胞生长因子激活黑素细胞而引起的。在基底细胞癌中，干细胞因子被怀疑与其色素沉着有关。我们在几种细胞系中研究了GRO-α在恶性黑色素瘤发生中的作用，并通过RT-PCR在大多数细胞系中发现mRNA的表达。这一发现可能提示GRO-α在黑色素瘤细胞的转化和进展中起重要作用。

Malignant melanoma is a poor prognostic skin tumor, which recurs and metastasizes frequently. Thus, it is important to know the mechanism of its genesis and progression. We studied the association of several factors which might have some roles in melanogenesis and genesis of that tumor, in comparison with other pigmentary skin disorder and tumors.In case of senile lentigo, keratinocyte derived Endothelin 1 is shown to be associated to melanogenesis. The pigmentation of overlying epidermis of dermatofibroma is brought by activation of melanocyte through up-regulation of Stem cell factor and Hepatocyte growth factor. In basal cell carcinoma, Stem cell factor was suspected to be associated with its hyperpigmentation. The role of GRO-α in the genesis of malignant melanoma was studied in several cell lines, and we found the expression of mRNA in most cell lines by RT-PCR. This findings may suggest the important role of GRO-α in transformation and progression of melanoma cells.