Regulation of HDL receptor SR-B1 and its role on lipid metabolism

Scanenger受体B1(SR-B1)是一种从高密度脂蛋白中摄取胆固醇酯的独特的高密度脂蛋白受体。因此，高表达SR-B1基因的小鼠表现出较低的高密度脂蛋白水平。尽管高密度脂蛋白含量较低，但高表达SR-B1基因的小鼠对配方饮食仍表现出抵抗力，本研究发现，在CETP缺乏患者中，SR-B1可将大的高密度脂蛋白重塑为正常的高密度脂蛋白颗粒。肝脏SR-B1mRNA的表达随胆汁酸分泌量的增加而增加。结论：SR-B1可使致动脉粥样硬化的大高密度脂蛋白转变为正常的抗动脉粥样硬化的高密度脂蛋白。

Scanenger receptor type B1 (SR-B1) is an unique receptor of HDL which uptake cholesteryl ester from HDL. Therefore, mouse which overexpress SR-B1 mRNA showed low HDL cholesterol concentration. In despite of low HDL cholesterol concentration, mouse which overexpress SR-B1 mRNA showed resistance against atherosclerotic formula diet.In our study, it was revealed that SR-B1 remodulate the large HDL that were observed in CETP deficient patient into normal HDL particle. And the expression of SR-B1 mRNA of liver was increased according to the amount of bile acid secretion. It may be concluded that SR-B1 may change the atherogenic large HDL into normal anti-atherogenic HDL.