The potential storage of peripheral nerve grafts using polyphenol

在大鼠坐骨神经模型中，评估了使用多酚的周围神经移植物的潜在储存。移植前用多酚或Dulbecco‘s改良Eagle培养液(DMEM)保存20 mm长的同种异体坐骨神经。新鲜神经也进行了同种异体移植。移植细胞在多酚处理的神经节段中比在培养基中储存的神经中保持更多的存活。移植后24周，经多酚处理的神经再生的组织学和电生理结果明显好于保存在DME介质中的神经，与新鲜神经移植的结果基本相同。这项研究显示了利用多酚进行组织保存的潜在能力。

The potential storage of peripheral nerve grafts using polyphenol was assessed in a rat sciatic nerve model. Isogenic sciatic nerve grafts 20 mm in length were stored either in polyphenol or Dulbecco's Modified Eagle Medium (DMEM) prior to transplantation. Isografting of fresh nerves was also done. Graft cells were kept more viable in the polyphenol-treated nerve segments than in the nerves stored in culture medium. The histological and electrophysiological outcomes of nerve regeneration through polyphenol-treated nerves was significantly better than those through nerves stored in DME medium and almost equal to those through fresh nerve grafts at 24 weeks postengraftment,. This study shows the potential ability of tissue preservation using polyphenol.