Neural mechanism of respiratory signal during general anesthesia

开展了多项临床和基础研究项目，从而发现以下发现：1)喉镜观察显示，在人类呃逆时，声门关闭是一个活跃的过程。2)在咪达唑仑镇静期间，鼻腔上游段的呼吸功增加，并在氟马西尼拮抗后恢复到基线水平。3)对于择期行耳鼻喉科手术的患者，坦度螺酮10 mg和30 mg可安全地降低术前焦虑，其程度与口服安定10 mg相似。4)在全麻下进行鼓室成形术的患者，术前口服他托螺酮可有效缓解恶心呕吐。5)我们提出了植物遗传学的观点，为呃逆的起源和生理意义提供了新的解释。

Several clinical and basic research projects were performed, thereby exhibiting the following findings.1) Laryngoscopic observation revealed an active process in glottic closure during hiccups in human.2) The work of breathing spent on the upstream segment of the nasal route increased during midazolam sedation and returned to baseline after flumazenil antagonism.3) Tandospirone, 10 and 30 mg, safely reduced preoperative anxiety to a similar extent as oral diazepam 10 mg in patients undergoing elective otolaryngologic surgery.4) Premedication with oral tandospirone is effective against postoperative nausea and vomiting in patients undergoing tympanoplasty under general anesthesia.5) We proposed a phylogenetic perspective that sheds a new light on the origin and physiological significance of hiccups.