Application study of High Intensity Focused Ultrasound for renal tumor

近年来发展起来的高强度聚焦超声(HIFU)系统聚焦能力强，能将超声能量转化为热量。剧烈的热冲击会立即导致凝固性坏死。HIFU治疗对肾脏肿瘤的作用已被提出。然而，HIFU在肿瘤中的潜在应用带来了关于精确消融、监测方法、剩余活肿瘤细胞和安全性的问题。目前还没有这样详细的评估报告。因此，我们在兔肾VX2肿瘤模型中对这些问题进行了评估。HIFU治疗体积与凝固性坏死量显著相关(r=0.84)。实验过程中未见出血及生命体征改变。结果表明，HIFU治疗兔模型具有消融准确、监测方法好、安全性高等优点。在不适当的治疗条件下，HIFU没有完全摧毁肿瘤，但在适当的条件下，在治疗区域内没有观察到残留的活肿瘤细胞。综上所述，这些结果表明，HIFU治疗肾脏肿瘤将是一个令人着迷的临床应用。

Recently developed High Intensity Focused Ultrasound(HIFU) system focuses sharply and converts the energy of the ultrasound into heat. The sharp heat impulse leads to an immediate coagulative necrosis. The effect of HIFU treatment on the renal tumor has been suggested. However, the potential use of HIFU for tumor raises the issue regarding precise ablation, monitoring method, residual viable tumor cells, and safety. No such detailed evaluation has been reported. Therefore, we evaluated these issues in rabbit kidney bearing VX2 carcinoma. HIFU-treated volume statistically significantly correlated with coagulative necrosis volume(r=0.84). In experimental procedure, bleeding and the change of vital sign were not observed. Our results showed the precise ablation, good monitoring method and safety of HIFU treatment in rabbit model. Under inappropriate treatment condition, no tumor was completely destroyed by HIFU, but under appropriate condition no residual viable tumor cell was observed inside the treated areas. In summary, these results demonstrate that HIFU treatment of renal tumor would be a fascinating clinical application.