Effects of Na/H and Na/Ca exchange inhibitors on ischemia/reperfusion arrhythmias

Na/H交换抑制剂已被我们和其他人证明可以抑制大鼠和狗的缺血/再灌注心律失常，改善血流动力学恢复并减少梗死面积。我们再次证实了使用新药FR 168888抑制Na/H交换的有效性。这种保护作用也涉及Na/Ca交换抑制，但一种新的Na/Ca交换抑制剂，SEA 0300，没有表现出对缺血/再灌注心律失常的保护作用。由于SEA 0300抑制洋地黄类心律失常，这被认为是由于钙超载，进一步的研究是必要的，以澄清在体内的作用机制的SEA 0300。

Na/H exchange inhibitors have been shown by us and by others to suppress ischemia/reperfusion arrhythmias in rats and dogs, to improve hemodynamic recovery and to decrease infarct size. We confirmed again the effectiveness of Na/H exchange inhibition using a new drug, FR168888. This protective effect also involve Na/Ca exchange inhibition, but a new Na/Ca exchange inhibitor, SEA0300, did not show protection against ischemia/reperfusion arrhythmias. Since SEA0300 suppressed digitalis arrhythmias, which is thought to be due to Ca overload, further investigation is necessary to clarify in vivo mechanism of action of SEA0300.