Pharmacological prevention of sudden cardiac death

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Sudden cardiac death (SCD) is a serious problem in cardiovascular patients, but the animal models for studying prevention of SCD have not yet establishd. We used coronary ligation/reperfusion induced and halothane-adrenaline arrhythmias to evaluate various cardioprotective drugs not including classical antiarrhythmic drugs, which have been shown to increase SCD. In these 3 years, we have demonstrated that Na/H exchange inhibitors are effective in decreasing arrhythmia death in in vivo animals, however Na/Ca exchange inhibitors and KATP channel openers or blockers have shown variable and mariginal protective effects.However electophysiological characteristics of these drugs have been clarified in more detail using voltage clamp and genetically modified ion channel proteins. We also evaluated transgeneic mice models which lacks sympathetic alpha or beta receptors and found shorter lives in some of these models, but partly due to the problems of evaluating mice long term ECG recordig we have not yet demonstrated whether these animals can be used to study preention of SCD.