Glycal approaches to the synthesis of biologically active compounds

该项目将侧重于对映选择性固体支撑合成天然和非天然脱氧偶氮糖和内酰胺，从不同的糖基开始。第一个目标是开发新的和有效的策略，以化学选择性保护和脱保护序列的羟基在聚合物结合的起始材料。按照这些策略，将从不同的糖基开始制备各种新化合物。所有新化合物的固相合成和生物活性，特别是糖苷酶抑制特性的研究是该项目的长期目标。

The project will be focused on the enantioselective solid-supported synthesis of natural and unnatural deoxy-azasugars and lactams starting from different glycals. The first goal ist the development of new and efficient strategies for chemoselective protection and deprotection sequences for the hydroxyl groups in the polymer-bound starting materials. Following these strategies, a variety of new compounds will be prepared starting from different glycals. Solidphase synthesis and examination of the biological activity, especially glycosidase inhibition properties, of all the new compounds represent the long term goal of the described project.