A population-based case-control study of pancreatic cancer

我们进行了一项以人群为基础的病例对照研究，以评估胰腺癌的风险与生活方式因素的关系，如吸烟，饮酒和咖啡消费以及营养摄入。病例为2000年1月至2002年4月间新诊断为胰腺癌的109例患者。对照对象是从选民登记册中随机选择的218人，并在性别、年龄和居住地方面进行匹配。生活方式因素的数据通过与病例组和对照组的面对面访谈收集。采用条件Logistic模型计算比值比及其95%可信区间。根据累积吸烟量和糖尿病史调整比值比。我们的研究证实，吸烟与胰腺癌风险增加有关，目前吸烟者的比值比为2.3。酒精和咖啡消费与胰腺癌风险无关。在有糖尿病史的患者中观察到风险增加（OR=2.4）。诊断前5年内体重减轻超过5 kg与风险增加相关;胆固醇摄入量最高的三分位数的受试者比最低的三分位数的受试者风险增加2倍。较高的维生素C摄入量显着降低了风险。我们的研究表明，述情障碍可能会增加胰腺癌的风险。

We conducted a population-based case-control study to evaluate the risk of pancreatic cancer in relation to lifestyle factors such as cigarette smoking, alcohol and coffee consumption and nutrient intake. Cases were 109 patients who were newly diagnosed with pancreatic cancer between January 2000 and April 2002. Control subjects were 218 persons who were randomly selected from the electoral register and were matched for cases on sex, age and residence. The data on lifestyle factors were collected by in-person interview with cases and controls. Conditional logistic model was used to calculate the odds ratios and their 95% confidence intervals. The odds ratios were adjusted for cumulative amount of cigarette smoking and history of diabetes. Our study confirmed that cigarette smoking was associated with an increased risk of pancreatic cancer, with the odd ratios being 2.3 for current smokers. Alcohol and coffee consumption were not associated with risk of pancreatic cancer. An increased risk was observed among those who had a history of diabetes (OR=2.4). The weight loss more than 5 kg within five years before the diagnosis was associated with an increased risk; Subjects in the highest tertile of cholesterol intake had 2-fold significantly increased risk than those in the lowest tertile. Higher vitamin C intake significantly decreased the risk. Our study suggested that alexithymia may increase the risk of pancreatic cancer.