Analysis of retinal function using P3-and derived P2-models and ON/OFF ERG responses

这项名为“使用P3及衍生的P2模型和ON/OFF ERG反应分析视网膜功能”的研究，试图使用杆状和锥体a波（P3）模型、衍生的P2模型和长闪刺激下的ON/OFF ERG反应分析正常对照和各种眼科疾病患者的视网膜功能。首先，我们记录了30名正常志愿者在200毫秒闪光灯刺激下的常规（暗位和光位）ERGs和ON/OFF反应，并测量了波分量（a-,b-,d-， op -波等）的振幅和峰值延迟的正常值。之后，我们计算p3的参数（Rm，S，td等），并推导正常对照的p2模型。不同眼科疾病(如：视网膜色素性视网膜炎、视网膜锥体营养不良、先天性视网膜裂、Oguchi病、维生素A缺乏症、视网膜中央静脉闭塞)与正常对照进行比较。同时对患者的其他眼科检查结果进行分析，包括视力、视野、眼压、暗适应曲线、基因分析。通过多次检查，客观准确地了解视网膜功能，对患者有一定的帮助。本研究显示的新的ERG方法可用于视网膜变性的基因治疗和视网膜移植。

The study, entitled "Analysis of retinal function using P3-and derived P2-models and ON/OFF ERG responses", tried to analyze retinal function in normal controls and patients with various ophthalmological diseases using rod and cone a-wave(P3) models, derived P2 model, and ON/OFF ERG responses to long flash stimulation.At first we recorded conventional(scotopic and photopic) ERGs and ON/OFF responses to 200 msec flash stimulation in 30 normal volunteers, and measured the normal values of amplitudes and peak latencies from the wave components (a-,b-,d-, OP-waves, and so on). After that, we calculated the parameters(Rm,S,td,etc) of the P3-and derived P2-models in normal controls. The values from various patients with ophthalmological disease(ex.retinitis pigmentosa, cone dystrophy, congenital retinoschisis, Oguchi disease, vitamin A deficiency, central retinal vein occlusion) were compared with those from normal controls. Other results of ophthalmological examinations, including visual acuity, visual field, ocular Hindus, dark adaptation curves, gene analysis, were also analyzed in the patients.It would be beneficial for patients to see the precise retinal function objectively from several examinations. New ERG methods to estimate retinal function shown in this study would be used in gene therapy and retinal transplantation in retinal degeneration in the near future.