Examination of application of photocatalyst titanium oxide in dentistry and mouth domain

提出了将TiO2光催化反应转化为生命物体(医疗器械和医药材料)利用的研究。利用杀菌效果，将二氧化钛包覆在口腔假体材料表面的二氧化钛微粒在口腔癌医疗中的应用。此外，还尝试了光照射在牙科医疗、TiO2光催化反应和口腔外科领域的医疗方面的应用。本研究旨在为口腔疾病安全医疗领域的高水平医疗手段的发展提供参考。研究二氧化钛光催化剂颗粒在口腔癌医疗中的应用。在口腔癌原代培养细胞(SCC、ACC)的培养液中加入抗肿瘤药物阿德利欣。加入后进行紫外线照射，体外检测抗肿瘤细胞…的水平效果更好。为了有效地介绍TiO2光催化剂颗粒在裸鼠(Balb/c)体内抗肿瘤作用的检测。在一种癌组织中制造了一种固体类型的癌(鳞癌和癌旁癌)，即将二氧化钛包覆在金色颗粒上的遗传枪的药筒。此外，用基因枪在肿瘤组织中驱动包被金的颗粒(二氧化钛)和抗肿瘤药物后，进行光学照射并进行抗肿瘤效果的检测，结合病理组织学观察，部分观察到抗肿瘤药物和光催化剂二氧化钛粘附金颗粒与所有上皮层。聚焦于大鼠口腔黏膜上皮角化层，由底部结缔组织的一层上皮作为微小的暗褐色颗粒。此外，改变在病理组织学研究中不被接受。未进行紫外光照射的组，植入抗肿瘤药物和光催化剂的二氧化钛粘附金。颗粒观察到气泡形成观和上皮缺损观(溃疡观)。病理组织学检查后1~2天取材。由此可知，紫外光照射开关调节抗肿瘤药物等药物的组织敏感性的模型效应发挥可以期待二氧化钛。现在，对药物的局部作用进行了检查，如抗肿瘤药物在病变部位(肿瘤组织)的作用。首先是关于医疗行为判断的实验。其次，在牙科龋病治疗时所用的树脂材料中加入二氧化钛，检测其防腐防菌效果。此外，对包括牙周病在内的口腔感染的预防细菌作用及其应用的实验检测仍在继续。较少

Research which turns a TiO_2 photocatalyst reaction to the utilization of a life object (medical apparatus and medicine material) is advanced. The application of oral cancer medical treatment by the sterilization effect, (guard dirty) and TiO_2 particle by coating of TiO_2 to the artificial material for dentistries. Additionally optical irradiation was tried for the purpose of application to the dentistry medical treatment of a TiO_2 photocatalyst reaction, and the medical treatment of an oral surgery domain. This research is considered the development of high medical treatment methods of safety to disease of dentistry mouth domain.Examination of the application to oral cancer medical treatment of TiO_2 photocatalyst particle TiO_2 particle. The antineoplastic drugs (adraremaishin) were used together in the culture solution of oral cancer origin established cultivation cell (SCC, ACC). UV irradiation after addition was performed, and the level of in vitro examined againtist cancer cell … More effect. In order to introduce efficiently the examination of TiO_2 photocatalyst particle about the anti-neoplasm effect in a nude-mouse (Balb/c). A solid type cancer (SCC and ACC) in a cancer organization, the cartridge of the heredity gun in which TiO_2 was coated to a golden particle was manufactured. Furthermore, after driving the coated particle with gold (TiO_2) and the antineoplastic drug in a neoplasm organization using a gene gun, optical irradiation was performed and examination of the anti-neoplasm effect was performed.With the pathology organization study-view, the antineoplastic drug and the photocatalyst TiO_2 adhesion golden particle were observed in part with all epithelium layers. Focusing on the cornification layer of rats mouth membrane epithelium by the bottom connective tissue of an epithelium as a minute particle of dark brown. Moreover, change was not accepted in the pathology organizational study. The group which did not carry out UV irradiation after inserting an antineoplastic drug and a photocatalyst TiO_2 adhesion golden. Particle observed the bubble formation view ad the epithelium deficit (ulcer view). Uunder the epithelium one-two days after pathology organizational study. It was suggested from this result that the model-effect exertion which adjusts the organizations susceptibility of medicines, such as an antineoplastic drug, by UV irradiation On-Off can expect TiO_2Now, examination about the local effect of medicines, such as an antineoplastic drug in a pathological change part (neoplasm organization), was performed. It started about the experiment of the judgment of the medical treatment. It effect by carrying out On-Off control a medicine from optical irradiation's.Second, TiO_2 was added to the resin material used at the time of dentistry dental caries medical treatment, and guard bacterium effect over dental caries was examined. Furthermore, the experimental examination towards guard bacterium effect over mouth infection including a periodontium disease and its utilization is continued. Less