EFFECT OF ADDITION OF ANTIBIOTICS ON PHYSICAL PROPERTIES OF AN EXPERIMENTAL CEMENT PREPARED FROM TETRACALCIUM PHOSPHATE AND POLY(METHYL VINYL ETHER-MALEIC ACID)

我们曾报道过聚甲基乙烯基醚-马来酸(PMVE-MA)与磷酸四钙共混可制得聚磷酸钙骨水泥(质量分数为20-30%)。本研究的目的是考察添加抗生素对实验骨水泥的机械强度和抗生素从骨水泥中释放的影响。本研究使用了甲硝唑、头孢克洛和环丙沙星三种抗生素。每种抗生素质量分数为5wt%的水泥粉与25wt%的PMVE-MA水溶液以3.0/1.0质量比的粉液比混合。水泥样品在37℃的水中浸泡。100h后测定释放的抗生素、钙和磷酸盐。浸泡24小时后，还测量了抗压强度。释放行为因添加的抗生素类型而异。在三种抗生素中，环丙沙星从骨水泥中的洗脱量最低。抗生素的加入增加了钙的洗脱。抗生素的加入不影响磷酸盐的洗脱。抗生素的加入降低了材料的抗压强度。抗压强度下降的程度因抗生素的类型而异。与市售的含有抗生素的磷酸钙骨水泥相比，头孢克洛的加入主要降低了抗压强度。

We previously reported that a polymeric calcium phosphate cement can be prepared by mixing tetracalcium phosphate with poly(methyl vinyl ether-maleic acid), PMVE-Ma (mass fraction=20-30%). The aim of this study was to examine the effects of addition of antibiotics on the mechanical strength of the experimental cement and the release profile of the antibiotics from the cement. Three kinds of antibiotics, Metronidazole, Cefaclor, or Ciprofloxacin were used in this study. The cement powders containing 5 wt % of each antibiotics were mixed with 25 wt% of PMVE-Ma aqueous solution at a powder/liquid ratio of 3.0/1.0 by mass. The cement samples were immersed in water at 37℃. The released antibiotics, Ca and phosphate were determined for 100 hours. The compressive strength was also measured after 24-hour immersion.The release behavior varied depending on the types of antibiotics added. The amount of Ciprofloxacin eluted from the cement was lowest in those of three antibiotics. The incorporation of antibiotics increased the elution of Ca. The elution of phosphate was not affected by the incorporation of antibiotics. The incorporation of antibiotics decreased the compressive strength. The degree of the decrease in compressive strength varied depending on the type of antibiotics. The addition of Cefaclor mostly lowered the value of the compressive strength, which compared to those of the commercially available calcium phosphate cements containing antibiotics.