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Drug Interactions between Sedatives and Analgesics in Rat Cerebral Cortical Synaptoneurosomes, Phospholipids Model Membrane, and Autonomic Nervous Activity

Drug Interactions between Sedatives and Analgesics in Rat Cerebral Cortical Synaptoneurosomes, Phospholipids Model Membrane, and Autonomic Nervous Activity
大鼠大脑皮层突触神经小体、磷脂模型膜和自主神经活动中镇静剂和镇痛药之间的药物相互作用
批准号:
13672116
负责人:
KUDO Masaru
金额:
$2.3万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2003

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中文摘要
翻译
目前,我们使用电细胞学谱图和(通过观察压力和紧张程度的病人的电心图实时分析进行行为观察,通过引入行为药理学观察装置进行行为观察,测试管使用无线同位素结合实验,激素提取的定量分析,对哪一种维生素的分析是一种使用质子-核磁共振的内分泌神经活性物质具有广泛的生物活性。2013年:公布的电信号谱图结果揭示了电信号谱成分:n波(13- 30 Hz)成分,当五氮杂素和中氮杂素都在一起时,并扩大了一种感性状态。同情心神经活动因五氮杂素而增加,但当中氮杂素减少了这些活动。因此,五氮杂素和中氮杂素对同情心神经的影响被发现是直接相反的行为。因五角大楼而增加的副疗法神经活动 ... More ocine,但用midazolam分解。将一个肾上腺素添加到口腔肌肉膜中的局部过敏解决方案注入体内,肾上腺素水平在肾上腺素血管中下降,但肾上腺素水平在女性细胞中增加。我们在两个小时后,在任何行政部门的焦虑或治疗条件中都没有发现任何影响。Nausea,诱惑后的投投和分化是由管理员的模拟引起的。我们无法找到一种合适的方法来管理两种疗法和模拟方法,以尽量减少两者的副作用。我们已经开发并合成了三氮唑-香豆素衍生物:3-(4-chloromethylthiazole-2-y)-7-dimethyl-aminochromen-2-one and 3-(5-乙酰-4-甲基硫唑-2-yl)-7-二氨基氯胺-2one,荧光衍生成形剂反对异丁素用于高性能液体色谱法,其中HPLS可用于荧光衍生成形剂,如在分析生物功能和生物okinetics时可应用。we would like to concentrate our studies in behavioral observations which can be applied to clinical studies, and to promote collaborative studies combining experiments using the electroencephalogram and electrocardiogram real time analysis with biochemical experiments, in an attempt to contribute our efforts to provide "successful operations,在牙科领域,对双方患者和医疗保健提供商的最佳条件下的治疗和例行操作管理。“Less”
英文摘要
Presently, we conducted the following general studies using the electroencephalogram and( electrocardiogram real time analysis through observation of the degree of stress and tension in patients, behavioral observation by introducing a behavioral pharmacological observation apparatus, test tubes binding experiments using radioisotopes, quantitative analysis of hormone excretions, with analysis of isatine which is an endogenous nerve active substance having broad biological activities using proton-NMR.・The results of the electroencephalogram revealed that the electroencephalogram component: n-wave (13-30Hz) component increased when both pentazocine and midazolam were given together and extended the sedative state.・Sympathetic nerve activities increased with pentazocine, while midazolam decreased these activities. Therefore, the effects of pentazocine and midazolam on the sympathetic nerves were found to be directly opposite actions.・Parasympathetic nerve activities increased with pentaz … More ocine, but decreased with midazolam.・With injection of an epinephrine-added local anesthetic solution to the oral mucous membrane, the epinephrine level in the adrenal veins decreased, but the epinephrine level increased in the femoral artery.・We found no effects from administration of either analgesics or sedatives in terms of anxiety two hours after sedation was completed.・Nausea, vomiting and dizziness after sedation were exacerbated by administering analgesics.・We could not find a suitable method of administering both sedatives and analgesics to minimize the side effects of both agents.・We developed and synthesized thiazole-coumarin derivatives: 3-(4-chloromethylthiazole-2-y)-7-dimethyl-aminochromen--2-one and 3-(5-acetyl-4-methylthiazole-2-yl)-7-diethylaminochromen-2one, fluorescent derivative forming agents against isatine for high performance liquid chromatography which are applicable as fluorescent derivative forming agents for HPLS when analyzing biological functions and biokinetics.In the future, we would like to concentrate our studies in behavioral observations which can be applied to clinical studies, and to promote collaborative studies combining experiments using the electroencephalogram and electrocardiogram real time analysis with biochemical experiments, in an attempt to contribute our efforts to provide "successful operations, treatments and routine operation management with adequate safety under optimal conditions for both patients and medical care providers in the field of dentistry." Less
期刊论文(22)
专著(0)
科研奖励(0)
会议论文
KUDO MASARU: "Efficacy of nitrous oxide/oxygen inhalation sedation dentistry-providing painless, safe, and comfortable dental treatment-"Medical Gas. 5(1). 21-27 (2003)
工藤胜:“一氧化二氮/氧气吸入镇静牙科的功效——提供无痛、安全、舒适的牙科治疗——”医用气体。
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通讯作者:
Masaru KUDO, et al.: "Positive correlation between the face anxiety scale and the state anxiety inventory in elderly Dental patients"HIGASHI NIPPON DENTAL JOURNAL. 22・1. 29-33 (2003)
Masaru KUDO 等:“老年牙科患者的面部焦虑量表与状态焦虑量表之间的正相关”《东日本牙科杂志》22・1(2003)。
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M.Kudo, H.Ohke, T.Kawai, et al.: "The Relationship Between trait Anxiety and Pain Sensation: Anxiety and Pain levels at puncture and Cannulation in High-Anxiety-State Volunteers"Anesth Prog. 48. 97-98 (2001)
M.Kudo、H.Ohke、T.Kawai 等人:“特质焦虑与疼痛感觉之间的关系:高度焦虑状态志愿者穿刺和插管时的焦虑和疼痛水平”麻醉进展。
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工藤 勝: "歯科における亜酸化窒素・酸素吸入鎮静法の有効性-痛くない,安心・快適な歯科医療を目指した笑気吸入鎮静法の有効利用-"Medical Gases. 5・1. 21-27 (2003)
Masaru Kudo:“一氧化二氮/氧气吸入镇静在牙科中的有效性 - 有效使用笑气吸入镇静实现无痛、安全和舒适的牙科护理”《医疗气体》21-27 (2003)。
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共 22 条
    Suppression of function in automatic nerve and elder rat brain synaptoneurosomes for aged cerebral infarction rats with administration of sedatives and analgesics
    • 批准号:
      17592101
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2005
    • 负责人:
      KUDO Masaru
    • 依托单位:
    海外基金