Epidemiologic studies on the screening for sleep disordered breathing in relation to cardiovascular diseases.

睡眠呼吸障碍(SDB)是一种睡眠期间呼吸气流减少或停止的反复发作。我们已经进行了几次调查，使用脉搏血氧仪在工作人口和社区中检测SDB。我们发现日本男性居民和工人中SDB的患病率与美国和欧盟国家相似。为了检查日本男性中SDB与血压水平的关系，我们在农村和城市社区男性中进行了一项基于人群的横断面研究。选择3%氧减饱和度指数(ODI)作为SDB的指标。ODI水平为3%的低、高类别高血压的多变量优势比为1.63(95%CI，1.1~2.5)。这些关联在超重的人中比非超重的人更明显。此外，我们还用夜间脉搏血氧饱和度测定仪对日本核电站的男性倒班工人和男性日间工作人员进行了ODI测量。在调整潜在的混杂变量后，所有受试者的收缩压和舒张压水平与3%的ODI显著相关(p=0.04)。这种关联主要是在40岁以上的工人中观察到的，更具体地说，是年龄较大的倒班工人。年龄[大于或等于]40岁的倒班工人的SDB严重程度和舒张压水平之间的相关性表明，在倒班工人中筛查SDB对于控制血压的重要性。为了阐明日常饮酒和夜间氧气减饱和之间的关联，我们根据酒精摄入量的类别比较了ODI水平。我们发现，在日本中年男性中，日常饮酒与SDB的严重程度之间存在显著的正相关，与年龄、BMI和吸烟无关。这种关联在非超重的受试者中更为明显，表明戒酒对非超重的SDB患者的重要性。

Sleep-disordered breathing (SDB) is a condition of repetitive episodes of decreased or arrested respiratory airflow during sleep. We have conducted several surveys using the pulse-oximetry to detect SDB in working populations and communities. We found that prevalence of SDB among male residents and workers in Japan was similar to that in the US and EU countries.To examine the relationship between SDB and blood pressure levels among Japanese men, we conducted a population-based cross-sectional study in rural and urban communities men. The 3% oxygen desaturation index (ODI) was selected as the indicator of SDB. The multivariate odds ratio of hypertension for the low versus high category of 3% ODI level was 1.63 (95% CI, 1.1-2.5). These associations were more evident among overweight than non-overweight individuals. In addition, we measured ODI by nocturnal pulse-oximetry among male shift workers and male day workers at nuclear power plants in Japan. Systolic and diastolic blood pressure levels were significantly correlated with 3%ODI in total subjects after adjustment for potential confounding variables (p=0.04). This association was primarily observed among workers aged 【greater than or equal】40 years, more specifically older shift workers. A correlation between SDB severity and diastolic blood pressure levels among shift workers aged 【greater than or equal】40 years suggests the importance of screening for SDB among shift workers for blood pressure control.To clarify the association between usual alcohol consumption and nocturnal oxygen desaturation, we compared ODI levels according to categories of alcohol intake. We found a significant positive association between usual alcohol consumption and the severity of SDB among middle-aged Japanese men, independent of age, BMI and smoking. This association was more evident among non-overweight subjects, indicating the importance of alcohol abstinence for non-overweight SDB patients.