Non invasive temperature measurement for brain tumor

我们研制出了针对恶性脑瘤的靶向脂质体。该脂质体含有磁共振增强材料，可在磁共振成像下识别化疗药物的分布区域。提出了一种基于磁共振(MR)成像的无创性评估颅内压(ICP)和脑组织顺应性的方法。逆分析的输入是通过相位对比MR速度成像获得的脑脊液流量，而估计函数是估计的动脉血流速度的平方误差。使用模拟大脑循环的体模进行的实验和数值模拟证实，所提出的技术产生了顺应性和压力的相关指数。对25名健康志愿者(22-63岁)和9名患者(27-69岁)的研究表明，健康组和患者组分布在明显不同的区域，由组织顺应性和颅内压指数组成的二维空间，证明了所提出的方法用于分类受试者的颅内生物力学特性状态的可行性和可行性。

We have developed target liposome for malignant brain tumor. This liposome contained MR enhanced materials which identify the distribution area of chemotherapy drugs under the MR imaging.A noninvasive method to evaluate intracranial pressure (ICP) and brain tissue compliance based on magnetic resonance (MR) imaging was proposed.Brain circulations, blood and cerebrospinal fluid (CSF) flows, was devised. The input for the inverse analysis was the CSF flow rate obtained by phase contrast MR velocity imaging, whereas the estimation function was the square error of the estimated arterial blood flow rate. Experiments using a brain-circulation-mimicking phantom followed by numerical simulations confirmed that the proposed technique yielded relative indices of the compliance and pressure. Studies on 25 healthy (22-63 years old) and 9 patient (27-69 years old) volunteers revealed that the healthy and patient groups distributed in significantly different regions in a two-dimensional space formed space formed by the indices of tissue compliance and intracranial pressure, demonstrating the feasibility and viability of the proposed technique for classifying the statuses of the intracranial biomechanical properties of the subjects.