Newly developed treatment for brain tumor under the MR temperature measurement

新开发的磁共振测温脑肿瘤治疗方法

• 批准号: 23592107
• 负责人: MATSUMAE Mitsunori
• 金额: $ 3.33万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592107/
• 关键词: MRI; 温度計測; レーザー治療; 化学療法; 画像情報; 脳腫瘍; 温熱治療; レーザー; DDS; 抗がん剤治療

MR temperature measurement using the water proton chemical shift technique represents a promising method for temperature monitoring in vivo. The novel diffuse- projection ®ber is clearly visualized in different optical penetrations upon MR temperature measurement. We detected the serious problem of carbonization around the laser ®ber tip and during LITT, and herein described a combination of two methodologies that regulated tempera- ture during LITT using MR temperature monitoring to reduce this risk of carbonization: the combined use of a diffuse-projection ®ber and the intermittent irradiation method. Temperature measurement by MR not only evaluates the temperature pro®les obtained by different ®ber systems, but also determines the appropriate irradia- tion method for the treatment of intracranial lesions.

使用水质子化学位移技术的 MR 温度测量代表了一种有前途的体内温度监测方法。在 MR 温度测量中，新型漫射投影光纤在不同的光学穿透度下清晰可见。我们检测到激光光纤尖端周围和 LITT 期间存在严重的碳化问题，并在此描述了两种在 LITT 期间使用 MR 温度监测来调节温度的方法的组合，以降低碳化的风险：漫射投影光纤和间歇照射方法的组合使用。 MR温度测量不仅可以评估不同ber系统获得的温度曲线，还可以确定治疗颅内病变的适当照射方法。