An experimental study about development of the ventilator for total liquid ventilation and its optimal respiratory setting.

然而，全液体通气（TLV）是治疗ARDS的有效方法，但仍存在CO2清除的问题。CO2去除性能取决于膜肺中液体侧和气体侧之间的压力差。在本研究中，我们开发了一种新的用于TLV的氧合器（TLV-OX）来改善这个问题，我们在体外测试了气体交换性能（GEP）。在新开发的TLV-OX中，气体流动长度从160 mm缩短到50 mm，并且气体入口增加到恒定地流动新鲜的100%02气体。在PFC下使用单路径方法评估GEP（全氟化碳）流量Q=0.75 L/min，气体流量比/PFC流量比V/Q =3、9、15、18，通过公式（1）计算：GEP=（TLV-OX进出口P02或PCO 2之差/大气压（760 mmHg））×本生系数× Q（1）在V/Q = 18时，新开发的TLV-OX的GEP为22.5mL/min，而原TLV-OX的GEP为18.9mL/min。本文认为，通过缩短气流长度和增加进气口，可以使PFC与血液之间的PCO_2差异保持在较高水平，并采用多目标遗传算法对TLV-OX进行优化设计，以提供较高的GEP。

However, Total Liquid Ventilation (TLV)is an effective treatment for ARDS, there still remain the problem about C02 removal. The C02 Removal performance depends on the pressure difference between Liquid side and Gas side in a membrane lung. In this study, we newly developed an oxygenator for TLV (TLV-OX)to improve this problem.We examined Gas Exchange Performance (GEP)in vitro. In newly developed TLV-OX, the gas flow length was shortened to 50mm from 160mm, and gas inlets were increased to flow fresh 100%02 gas constantly. GEP was evaluated using the single path method under PFC (Perfluorocarbon) flow rate of Q=0.75 L/min and gas flow ratio/PFC flow ratio of V/Q =3,9,15,18,and calculated by the equation(1) :GEP=(difference in P02 or PCO2 between inlet and outlet of TLV-OX/atmosphere pressure (760mmHg))X bunsen coefficient X Q (1)The newly developed TLV-OX was shown to be 22.5mL/min, and the previous TLV-OX was 18.9mL/min in V/Q =18.GEP the of newly developed TLV-OX was increased by 15.9% compared with the previous TLV-OX.In conclusion, it was considered that the difference in PCO2 between PFC and blood was kept at a high level by shortening the gas flow length and with an increase of gas inlets.We will optimize TLV-OX design to offer a high GEP using a Multi Objective Genetic Algorithm.