The study of early detection of incipient dental caries

本研究旨在通过定量光诱导荧光（QLF）评价含氟牙膏对白色斑病变矿化的有效性。145名10岁以上的志愿者提供了知情同意书。他们被随机分配到两组，一组为含950 ppm氟化物的试验组，另一组为安慰剂对照组。分别于基线检查后6个月和12个月进行QLF复查。通过计算从基线测量值减少的矿物质损失百分比（Δ Q）来评价试验和安慰剂的有效性。12个月后，试验组的Δ Q降低了88%，而安慰剂组降低了43%。据认为，QLF系统满足了重要部分的要求，作为一个有效的诊断工具。临床试验表明，含氟牙膏具有最大的矿化潜力。因此，可以将QLF法评价釉质亚表面病变作为龋病风险评价的一个主因子，在早期准确评价龋病高危人群。此外，它可能导致发展的有效性评估的第二龋表现的龋病治疗和新的预防措施的代理。该临床研究的结果清楚地证明了氟化物治疗剂对临床白色斑病变的逆转和再矿化的影响，特别是QLF监测和量化这种影响程度的能力。由于使用常规龋齿检测方法在许多场合已经临床证明了氟化物龋齿的影响，因此这些数据表明QLF能够使用相对较小的受试者组和缩短的时间段来量化这种影响。

The study aimed to evaluate the effectiveness of dentifrice containing fluoride on remineralization of white spot lesions by use of QLF (quantitative light-induced fluorescence). Informed written consents were obtained from 145 volunteers aged over 10 years old. They were allocated randomly to two groups, one for test dentifrice containing 950 ppm fluoride, the other for placebo control. They were re-examined at three times, six and twelve months after baseline examination by QLF. The effectiveness of the test and placebo dentifrice were evaluated by calculating percentage reduction in mineral loss (delta Q) from the baseline measurement values. After twelve month, 88% reduction in delta Q in the test group, whereas 43% reduction was observed in the placebo dentifrice group. It is thought that QLF system satisfies significant parts of requirements as a validated diagnostic tool. It could be showed that dentifrice containing fluoride has the highest potential of remineralization by clinical trial. We can add the evaluation of enamel subsurface lesion with QLF method as a host factor to caries risk assessment and evaluate precisely a high risk for dental caries at early stage. Furthermore, it may lead to development of effectiveness evaluation of second caries manifestation of caries treatment and new prevention measures agent. The results of this clinical study clearly demonstrate the impact of a fluoride dentifrice upon the reversal and remineralization of clinical white spot lesions and particularly the ability of QLF to monitor and quantify the magnitude of this effect. Since the impact of fluoride dentifrices have been clinically demonstrated on numerous occasions using the conventional caries detection methods, these data indicate the ability of QLF to quantify this effect using a relatively small panel of subjects and a reduced time period.