Regulation of autophagy by microproteins and RNA modifications (F05*)

我们的初步数据显示，在自噬中断或感染鲍曼不动杆菌时，几种微蛋白显著上调或下调。基于这一观察结果，本项目试图描述调节微蛋白与自噬之间相互作用的潜在分子机制，并评估自噬相关微蛋白在感染时的调节。其中一个重点将是tRNA修饰作为异噬背景下微蛋白表达的关键调节剂。

Our preliminary data revealed several microproteins that are significantly up- or downregulated upon autophagy disruption or infection with Acinetobacter baumannii. Building up on this observation, this project seeks to characterize the underlying molecular mechanisms that regulate the interplay between microproteins and autophagy and to assess the modulation of autophagy-related microproteins upon infection. One focus will be on tRNA modifications as key modulator of microprotein expression in the context of xenophagy.