Study on sensing of plural measurement of biosignals for the control of neuro-muscular control

结果表明，功能性电刺激（FES）可以恢复因螺旋索或皮质区损伤而导致的严重运动障碍患者的肢体瘫痪功能。但在目前的FES系统上，由于FES用户需要使用他们剩余的身体功能来控制FES刺激器，因此功能受到限制。并通过FES刺激产生的姿态或张力评价患者肢体物理功能的恢复质量。需要用更多的定量方法来评价这种恢复的物理功能的质量。在本研究中，(1)FES患者通过检测使用者的大脑活动或眼动，以自己的意图控制刺激装置的人机界面或脑机接口（BCI）；(2)利用外周循环系统的代谢特性对FES恢复的身体功能进行定量评价的方法。通过对生物信号的多重测量来研究和开发，以改善当前FES系统的功能。首先，开发了利用眼电图（EOG）和用户眼球视频图像检测眼球注视的人机界面系统，以控制FES刺激器。其次，开发了脑机接口（BCI）系统，用于检测用户在运动想象或选择性注意听觉刺激时的脑电图（EEG）强度，并研究了其应用于FES刺激器自主控制的能力。第三，提出了检测外周循环系统代谢特性的光声显微镜系统。该系统实现了人体局部温度的高精度测量，并介绍了利用时间序列分析对测量温度进行分析的方法。

It was shown that the functional electrical stimulation (FES) could restore motor function of paralyzed limbs of the patients with severe motor disabilities due to the spiral cord or cortical area injuries. But on the current FES system, the abilities was limited because the FES users should control the FES stimulator by using their remained physical functions. And the quality of the restored physical functions of the patients' limbs have been evaluated the posture or tension generated by FES stimulation. It is needed to evaluate such a quality of the restored physical function by using more quantitative ways.In this study, (1) the human interface or brain-computer interface (BCI) which enables the FES patients to control the stimulation devices by their own intensions by detecting the brain activities or eye movements of the users, and (2) the quantitative evaluation methods of the restored physical functions by FES using metabolic properties of the peripheral circulation system, were investigated and developed by the plural measurement of biosignals for improving the functionality of the current FES system.First, the human interface systems to detect eye-gaze from electrooculogram (EOG) and video image of eye ball taken from user to control FES stimulator were developed.Second, the BCI system to detect user's intension from electroencephalogram (EEG) during motor imagery or selective attention to the auditory stimuli was developed and the ability to apply to the voluntary control of FES stimulator was investigated.Third, the Photoacoustic Microscopy system to detect metabolic properties of the peripheral circulation system was proposed. The high-precision measurement of body local temperature was achieved by the proposed system, and the analysis method of the measured temperature by using temporal sequence analysis was introduced.