Study on motor function imaging developed for quantitative evaluation of rehabilitation effects

本研究的目的是证明运动功能成像的可能性，通过使用微波成像模式称为CP-MCT，是由我们的团队开发的。成像方式基本上可视化微波在生物组织中的衰减和/或相移的横截面分布。由于CP-MCT的重建图像反映了组织的物理或化学变化，因此预计康复效果将通过主要在肌肉中的物理或化学变化来可视化。为了可视化运动的效果，在前臂肌肉上施加握力负荷5分钟。为了观察肌肉物理或化学参数的细微变化，通过图像减法对运动前后的图像进行比较。通过肌电成像和光学扩散成像监测抓握载荷下肌肉的生理状态，并尝试对前臂相应部位进行更多的检测，以获取肌肉氧化的信息。两幅CP-MCT图像之间的图像相减可以清晰地显示骨骼区域，因为骨骼区域的灰度值没有变化。相反，其他区域的灰度分布不均匀，可能是由于肌肉活动的差异。事实上，在一些实验中，肌电图证实了肌肉的疲劳。光学扩散断层扫描显示各种肌肉和血管的氧化过程。其中一些图像显示氧和脱氧血红蛋白的合理分布。虽然在本研究中没有发现光学扩散图像与减去的CP-MCT图像之间存在很强的相关性，但灰度变化区域却表现出非常相似的特征。因此，通过改进测量技术，利用啁啾脉冲微波来评估康复效果是可行的。少

The objective of this study is to demonstrate the possibility of motor function imaging by use of the microwave imaging modality called CP-MCT that was developed by our groups. The imaging modality basically visualizes the cross-sectional distribution of the attenuation and/or phase shift of microwaves in the biological tissues. Since the reconstructed image of CP-MCT reflects the physical- or chemical-change in the tissues, it is expected that rehabilitation effects are visualized through those physical- or chemical changes mainly in the muscles In order to visualize the effects of exercise, gripping loads were applied to the forearm muscles for 5 minutes. To observe slight changes in the physical- or chemical parameters of the muscle, images obtained before and after having exercises were compared by means of image subtraction between those two images. The physiological condition of muscles under gripping load was monitored by means of electromyography and the optical diffusion imagi … More ng of the corresponding forearm portions was also attempted to gain access information of oxidization in the muscles.The image subtraction between two CP-MCT images revealed the bone regions clearly, because the gray level did not change in the bone regions. Conversely, the gray level in the other regions showed an uneven distribution probably due to the difference in the muscle activities. In fact, fatigue of muscles was confirmed by the electromyography in some experiments. The optical diffusion tomography showed oxidization processes in various muscles and vessels. Some of those images showed a reasonable distribution of oxi- and deoxi-hemoglobin. Although the strong relationships between the optical diffusion image and subtracted CP-MCT image were not found in this study, the areas of gray level change showed close resemblance. Therefore, it will be concluded that new modality using chirp pulse microwaves will be used for evaluating the rehabilitation effects by improving the measurement techniques. Less