Development of Computeraided Diagnosis System for Evaluation of Regional Pulmonary Blood Flow by use of Different Thee Phase of MDCT Images

我们的研究成果概括为以下四个方面：1.区域肺血流分析我们提出了一种基于非立体配准算法的减影算法，利用增强和非增强的多层螺旋CT图像来评价肺血流异常。我们开发了一种从体MDCT数据中提取周围肺血管的算法。我们的算法对于弥漫性肺部疾病的诊断是有用的。我们还开发了一种检测急性肺栓塞症的算法。肺呼吸功能分析慢性阻塞性肺疾病是肺呼吸功能分析的指标之一。为了诊断慢性阻塞性肺疾病，我们开发了一种支气管径向测量。此外，对于肺气肿的评估，我们还开发了一种肺叶分割算法。此外，我们还开发了一种利用吸气和呼气MDDCT图像测量肋骨和横隔膜位移的算法。弥漫性肺疾病的分析弥漫性肺疾病是我们研究的对象之一。我们开发了一种基于多层螺旋CT体积数据的全肺弥散分析算法。在我们的算法中，全肺被诊断为七种弥漫性肺部疾病模式之一。听诊声音分析为了评估肺炎和慢性阻塞性肺病等肺部疾病，我们开发了一种听诊声音算法。对听诊声音的辨别达到90%以上的识别率。

The outline of our research results is summarized to the following four items :1. Regional Pulmonary Blood Flow AnalysisWe have developed a subtraction algorithm for evaluation of pulmonary blood flow abnormalities based on non-solid registration algorithm by use of enhanced and non-enhanced MDCT images. We have developed an extraction algorithm of peripheral pulmonary vessels from volume MDCT data. Our algorithm is useful for diagnosis of diffuse lung diseases. We have also developed a detection algorithm of acute pulmonary embolisms.2. Function Analysis of Pulmonary RespirationCOPD is one of targets for function analysis of pulmonary respiration. For the diagnosis of COPD, we have developed a radial measurement of bronchus. And also, for the evaluation of emphysema, we have developed an algorithm of lobar segmentation. Moreover, we have developed a measurement algorithm of displacements for ribs and diaphragms by use of inspiratory and expiratioy MDDCT images.3. Analysis of Diffuse Lung DiseaseDiffuse lung disease is one of targets for our study. We have developed an algorithm of diffuse lung analysis for whole lungs obtained from MDCT volume data. In our algorithm, whole lungs are diagnosed as one of seven diffuse lung disease patterns.4. Analysis of Auscultation SoundsFor evaluation of pulmonary diseases, such as pneumonia and COPD, we have developed an algorithm of auscultation sounds. We have achieved more than 90% recognition rate for differentiation of auscultation sounds.