STUDY OF MECHANISMS FOR GRAFT ACCEPTANCE AND ESTABLISHMENT OF STRATEGY IN HUMAN BLOOD TYPE INCOMPATIBLE LIVER TRANSPLANTATION

本研究揭示了补体和B细胞表型的改变在血型不合肝移植中抗体介导的排斥反应中的作用。此外，我们建立了使用抗CD-20抗体克服抗体介导的排斥反应的策略，并显示了效果的机制。为了进一步改善预后，我们研究了CD 8阳性细胞在移植后感染中的作用，这是抗体介导的排斥反应终止后患者死亡的主要原因。我们发现CD 8阳性细胞表型在术后病程中占优势的意义，我们正在进行一项前瞻性研究，以根据CD 8阳性细胞表型库定制免疫抑制。

We disclosed the role of compliment and the change of B cell phenotype in antibody mediated rejection in blood type incompatible liver transplantation. Further, we established the strategy to overcome the antibody-mediated rejection using anti-CD-20 antibody and showed the mechanisms of the effects. In order to improve the outcome further, we investigated the role of CD8 positive cells in posttransplant infection, which was the major reason of patient's death after termination of antibody-mediated rejection. We found the significance of dominancy of phenotype of CD8 positive cell in postoperative courses and we are carrying on a prospective study to tailor immunosuppression based on the CD8 positive cell phenotype repertory.