Cyclophane Carbene Complexes as Catalysts: An Integrated Synthetic, Structural, and Mechanistic Approach

金属-卡宾络合物正在成为制药和精细化学工业中非常重要的化学过程的有效催化剂。该项目将建立在最近发现的一系列络合物的基础上，这些络合物在碳-碳键形成反应中显示出迄今报道的金属-卡宾催化剂的最高活性。对新催化剂工作方式的深入了解将通过合成、机械和结构研究相结合的方式获得。这种对结构/反应活性关系的详细研究将有助于理解为什么这些催化剂如此高效，从而为开发适用于工业应用的优质新型催化剂提供合成线索。

Metal-carbene complexes are emerging as efficient catalysts for chemical processes of immense importance to the pharmaceutical and fine chemicals industries. This project will build on the recent discovery of a family of complexes that exhibits the highest activity yet reported for metal-carbene catalysts in carbon-carbon bond-forming reactions. Insights into the ways the new catalysts work will be gained through a combination of synthetic, mechanistic, and structural studies. This detailed investigation of structure/reactivity relationships will provide an understanding of why these catalyst are so efficient and hence give synthetic leads for the development of superior new catalysts suitable for industrial application.