The relationship between exercise habits and redox state of serum albumin in middle and old-aged People

本研究于2005年至2007年三年间，探讨中老年人运动习惯、血管年龄与血清白蛋白氧化还原状态的关系。对50 ~ 83岁的受试者进行了人血清白蛋白氧化还原状态（HMA：巯基白蛋白、HNA 1：非巯基白蛋白1和HNA 2：非巯基白蛋白2的分数（%））、血管年龄（加速法）和运动量（生命编码系统）的测量，并调查了健康和生活习惯。结果如下：1.年龄、血管年龄与HMA、HNA 1、HNA 2各组分间无显著相关性。然而，HMA分数与运动量、%EE（运动量占每日总能量消耗的百分比）和每日步数之间存在显著正相关。HNA 1分数与运动量、%EE和每日步数呈显著负相关，HNA 2分数与运动量、%EE和每日步数呈显著负相关.为了进一步分析HMA、HNA 1和HNA 2各组分与运动量之间的关系，对两名受试者连续4周监测这些参数，结果在此期间未观察到相互作用，表明每日运动量可能是影响人血清白蛋白氧化还原状态的主要因素。因此，在本研究的受试者的运动负荷范围内，认为大的运动负荷可以与防止生物老化相关联。

This study was investigated on the relationship among exercise habits, vascular age, and redox state of human serum albumin in middle and old-aged people during three years from 2005 to 2007. Subjects aged 50 to 83 years were measured on redox state (fractions(%) of HMA: mercaptalbumin, HNA1: nonmercaptalbumin 1 and HNA2: nonmercaptalbumin 2) of human serum albumin, vascular age (by acceleration method) and amount of exercise(by life coder system), and surveyed about health and lifestyle habits. The results were as follows:1. No significant correlations were found among chronological age, vascular age and each fraction of HMA, HNA1 and HNA2.2. However, a significant positive correlations were found between HMA fraction and amount of exercise, %EE (percentage of amount of exercise to total energy expenditure per day), and number of steps per day. Significant negative correlations were found between HNA1 fraction and amount of exercise, %EE and number of steps per day, and also between HNA2 fraction and amount of exercise, %EE, and number of steps per day.3. In order to further analyze the relationship between each fraction of HMA, HNA1, and HNA2, and amount of exercise, these parameters were monitored continuously for four weeks for two subjects, with the result that no interaction was observed during that time period.Above results indicate that amount of exercise per day may be a primary factor affecting redox state of human serum albumin. Accordingly, within the range of exercise loads of the subjects in this study, it is thought that large exercise loads can be connected with prevention of biological aging.