Research on molecular epidemiology and patient education system in obesity and metabolic syndrome

肥胖及其相关疾病如代谢综合征（MetS）是近年来的公共问题。单核苷酸基因多态性（SNPs）在代谢综合征中的研究正在进行中，SNPs在患者教育和预防医学中的应用是一个问题。我们的项目旨在调查一些SNPs与MetS组分疾病之间的关联，并尝试在考虑行为科学和SNPs时对患者进行教育。首先，我们的横断面研究发现了以下发现：1）关于血管紧张素II 2型受体3123 AC SNP，CC型女性比非C等位基因携带者表现出更高的体重指数或HbAlc水平。2)关于解偶联蛋白I（UCPI）-3826AG SNP，GG型受试者具有有利的HDL胆固醇状态，而GG型男性或老年受试者（？）60岁）高血压的发生率高于非G等位基因携带者。在非药物干预减肥实验中，β_3肾上腺素能受体（β_3AR）Trp 64 Arg SNP中Arg携带者表现出减肥抵抗或血脂改善，而UCP 1 - 3826 AG SNP中G等位基因携带者也表现出减肥抵抗。一方面，在短期（至少1年）的患者减肥教育实践中，加强体重记录行为似乎是一种有效的方法，比目前包括β_3AR Trp 64 Arg SNP在内的其他方法更好。然而，目前的研究是一个小的和初步的研究，特别是在病人的教育，所以需要更多的研究。

Obesity and its related disorders such as metabolic syndrome (MetS) are public problems in recent days. Research on single-nucleotide gene polymorphism (SNPs) in MetS is in progress, and the applications of the SNPs to patient education and preventive medicine are an issue. Our project is aimed at investigating the association between some SNPs and MetS component disorders, and trying the patient education in considering the behavioral science and the SNPs. First, our cross-sectional studies found the following findings: 1) regarding angiotensin II type 2 receptor 3123AC SNP, the CC-typed women exhibited a greater level of body mass index or HbAlc than the non-carriers of C-allele. 2) regarding uncoupling protein-I (UCPI) -3826AG SNP, the GG-typed subjects had a favorable state of HDL cholesterol, and the GG-typed men or older subjects (? 60 years) had a higher occurrence of hypertension, compared to the non-carriers of G-allele. Next, in a non-pharmacological intervention study for weight reduction, the Arg-carriers in the β_3adrenergic receptor (β_3AR) Trp64Arg SNP showed resistance to weight reduction or improved lipid profiles, and the G-allele-carriers in UCP1 -3826AG SNP also showed resistance to weight reduction. These results suggest weak but significant effects of these SNPs on the MetS component disorders and weight reduction.On one hand, in practice on a short-term (at least during 1-year) patient education for weight reduction, reinforce of weight record behaviors seems to be an effective and better method than others including the announcement on β_3AR Trp64Arg SNP presently. However, the present is a small and preliminary study especially in patient education, so more studies are needed.