A new dietary approach for prevertion of osteoporosis -osteogenic functions of plant foods-

1.基础研究新开发的蔬菜小豆的水提物能增加人成骨细胞系BMP和骨保护素的mRNA表达。此外，我们还发现，没食子酸，一种从富含蔬菜和茶叶的水解性单宁中提取的多酚，可以增强碱性磷酸酶的活性，这是成骨细胞分化的标志。结论1.通过低钙饲料喂养断奶大鼠4周建立的成骨障碍动物模型，发现植物源性单萜香叶醇可改善股骨远端骨小梁的微结构，降低血清甲状旁腺激素和骨吸收标志物环磷酰胺的水平。297名18~22岁女生跟骨超声评价指数(OSI)随年龄增长呈下降趋势。体重、体重指数、初潮年龄、运动、能量、脂肪和碳水化合物的摄入量与21岁时的OSI相关，但与4年间的OSI下降率(ΔOSI)无关，而ΔBMI与ΔOSI相关，但与21岁时的OSI无关。在21岁时，不吃早餐的习惯与AOSI和OSI均呈负相关。在179名成年肥胖女性中，绝经后女性的OSI水平显著低于绝经前女性，而腹部内脏脂肪面积(VFA)、总胆固醇和低密度脂蛋白水平高于绝经前女性。尽管绝经前妇女的OSI水平与体重、BMI、腹部皮下脂肪面积(SFA)和瘦素呈正相关，但绝经前妇女的OSI水平与体重、BMI、腹部皮下脂肪面积(SFA)和瘦素呈正相关。调整年龄和VFA后，绝经后妇女腹部SFA与总胆固醇和低密度脂蛋白呈负相关。

1. Basic studyThe water-extracts of a newly developed vegetable, petit vert, was found to increase the mRNA expression of BMP and osteoprotegerin of the human osteoblast cell line. In addition, we found gallic acid, a polyphenol derived from hydrolyzable tannin which is rich in vegetables and tea, enhanced the alkaline phosphatase activity, an osteoblat-differentiation marker. By using an animal model of impaired osteogenesis developed by feeding weanling rats with a Ca-deficient diet for 4weeks, a plant-derived monoterpene, geraniol, was found to improve the micro-architecture of trabecular bone of the distal part of femur and lower the serum levels of parathyroid hormone and CTX, a bone absorption marker.2. Clinical studyThe calcaneus osteo sono assessment index (OSI) of 297 female students, ranging in age from 18 to 22 years, were found to be decreased with age. Body weight, BMI, age at menarche, exercise, and intakes of energy, lipid and carbohydrate correlated with the OSI at the age of 21 but not with the reduction rate of OSI during 4 years ( Δ OSI), whereas Δ BMI correlated with Δ OSI but not with the OSI at the age of 21. The habit of skipping breakfast negatively correlated with both A OSI and the OSI at the age of 21. Among 179 adult obese women, postmenopausal women showed significantly decreased levels of OSI and increased levels of abdominal visceral fat area (VFA), total cholesterol and LDL cholesterol as compared with premenopausal women. Although the OSI levels in premenopausal women positively correlated with body weight, BMI, abdominal subcutaneous fat area (SFA), and leptin, those in premenopausal women did not. Abdominal SFA of postmenopausal women negatively correlated with total cholesterol and LDL cholesterol after adjustment for age and VFA.