The Role of Side Population Cell in Skeletal Muscle on post infarcted LV remodeling

尽管药物治疗和机械干预取得了进展，但心肌梗死（MI）期间丢失的心肌细胞无法再生。因此，MI中心肌细胞的损失是心力衰竭的主要原因。作为一种潜在的方法，心肌细胞移植已经研究了十年。骨骼肌侧群细胞移植在实验上可能成为治疗心脏损伤的潜在方法。但其移植的安全性、有效性存在争议。本研究旨在探讨骨骼肌侧群细胞是否可以作为良好的细胞来源。本研究将骨骼肌侧群细胞移植到小鼠心肌梗死模型中，观察移植的骨骼肌侧群细胞是否改善心肌梗死后的心功能，以及骨骼肌成肌细胞侧群细胞能否在体内外转分化为心肌细胞。

Despite the advance in pharmacotherapeutics and mechanical interventions, the cardiomyocytes lost during myocardial infarction (MI) cannot be regenerated. Consequently, the loss of cardiomyocytes in MI is a major cause of heart failure. As a potential method, cell transplantation to myocardium has been studied for a decade. Side Population Cell in Skeletal Muscle transplantation could be potential therapy for heart damage in experimentally. However, the safety, efficacy of their transplantation are controversial. In this study, we investigate that whether Side Population' Cell in Skeletal Muscle can be a good cell source. In the present study, we transplanted Side Population Cell in Skeletal Muscle into infracted mouse hearts and investigate that (1) whether engrafted Side Population Cell in Skeletal Muscle improve post infarcted cardiac function, (2) whether Side Population Cell in Skeletal Muscle myoblasts can transdifferentiate into cardiomyocytes in vitro and in vivo.