Cellular Responses to Oxidative Damage: Cell Aging

这个项目的目的是确定氧化应激和自由基损伤导致细胞衰老的机制。这项工作将通过识别导致细胞衰老的主要活性氧物种、哪些防御系统和抗氧化剂提供最大程度的保护、随着细胞老化而积累的损伤以及在此过程中激活的遗传系统，为我们理解细胞的衰老过程做出重要贡献。

The aim of this project is to identify the mechanisms by which oxidative stress and free radical damage cause cell aging. This work will make a significant contribution to our understanding of the aging process in cells by identifying the major reactive oxygen species that contribute to cell aging, which defence systems and antioxidants provide the greatest degree of protection, what damage accumulates as cells age and which genetic systems are activated as during the process.