Investigation of the retinal function and pathogenesis in diabetic retinopathy

1.人类研究，血液流动可能在早期阶段消退，但在晚期阶段后消退（提交）。增加的RBF可能预测患者患有2型糖尿病的糖尿病视网膜病变的发展（在提交中）。2型糖尿病患者中没有增加的等离子体水平。（Japanese J Ophthalmol， 2006年）·II型血管紧张素受体的阻塞没有改变健康对象中的视网膜血流（在提交中）。血管内分泌失调可能会在患者与慢性肝炎C的病理学中发生干扰素诱导视网膜病理学的病理学。（Invest Ophthalmol Vis Sci， 2007）·2。在体内动物研究·Nitric oxide contributes to RBF recovery after hyperoxia，可能通过the action of endothelial NOS via the ETB receptor in the vascular endothelium of the retinal arterioles，建议RBF response to hyperoxia may be used to evaluate the endothelial function of the retinal arterioles。（在Su ... More bmission）。急性超ycemia有意义地减少了内皮依赖BK诱导的增加在容器直径、出血速度和视网膜血流量中，建议说每个细胞的超ycemia可能会导致视网膜细胞的急性内变性函数。（in submission）。3.在体外动物研究中，Simvastatin elicis主要是通过激活guanylyl cyclase的内氟胺-依赖的、无介导的修饰（Invest Ophthalmol Vis Sci， 2007年）;和Resveratrol elicis endothelium-依赖的和独立的修饰。内皮素依赖性置换是由释放的NO介导的，可能通过NO合成酶（NOS）激活由ERK途径和溶解瓜基环酶的亚序激活。（Invest Ophthalmol Vis Sci， 2007）·CRP抑制内皮素依赖的NO介导的降解，通过NAD（P）氧化酶产生超氧化物，出现与p38激酶和RhoA/Rho-kinase激活相连的。（Invest Ophthalmol Vissci， 2008）

1. Human research・The retinal blood flow may decrease in the early phase but increase in the late phase after the onset of diabetes mellitus (in submission).・The increased RBF may predict development of diabetic retinopathy in patients with type 2 diabetes (in submission).・The plasma level of NO increases in patients with type 2 diabetic patients. (Japanese J Ophthalmol, 2006)・Blockade of angiotensin type II receptor did not change retinal blood flow in healthy subjects (in submission).・Vascular endothelial dysfunction may be involved in the pathogenesis of interferon-induced retinopathy in patients with chronic hepatitis C. (Invest Ophthalmol Vis Sci, 2007)・2. In vivo animal study・Nitric oxide contributes to RBF recovery after hyperoxia, probably through the action of endothelial NOS via the ETB receptor in the vascular endothelium of the retinal arterioles, suggesting that the RBF response to hyperoxia may be used to evaluate the endothelial function of the retinal arterioles. (in su … More bmission).・Acute hyperglycemia significantly reduced the endothelial-dependent BK-induced increase in vessel diameter, bleed velocity and retinal blood flow, suggesting that hyperglycemia per se may induce the acute endothelial dysfunction of retinal arteries. (in submission).・3. in vitro animal study・Simvastatin elicits mainly an endothelium-dependent, NO-mediated dilation of retinal arterioles via activation of guanylyl cyclase (Invest Ophthalmol Vis Sci, 2007)・Resveratrol elicits endothelium-dependent and-independent dilation of retinal arterioles. Endothelium-dependent dilation is mediated by the released NO, probably via NO synthase (NOS) activation by the ERK pathway and the subsequent activation of soluble guanylyl cyclase. (Invest Ophthalmol Vis Sci, 2007)・CRP inhibits endothelium-dependent NO-mediated dilation in retinal arterioles by producing superoxide from NAD(P)H oxidase, which appears to be linked with p38 kinase and RhoA/Rho-kinase activation. (Invest Ophthalmol Vis Sci, 2008) Less