Development of diagnostic tools and treatment based on the specific immune responses of VKH disease

为了建立诊断VKH病的可靠实验室检查方法，我们研究了VKH病特异性T细胞受体（TCR）。针对VKH的TCR库，我们制备了VKH特异性TCR库抗原，但目前还难以获得VKH特异性TCR抗体，也难以建立VKH特异性调节性树突状细胞。眼内组织中存在多种摄取多肽抗原的细胞。这些细胞可分为3 ~ 4组，这些细胞组具有不同的细胞表面标志，可能发挥不同的功能。在脉络膜组织中，这些细胞可以作为刺激T细胞的APC发挥作用，而在视网膜中，这些细胞可以作为调节T细胞/T细胞的APC发挥作用。

To develop the reliable laboratory examination for diagnosis of VKH disease, we studied the T cell receptors (TCRs) specific for VKH disease. The antigens were raised against the TCR pools specific for VKH.It was difficult to get the antibodies specific against TCRs from VKHdisease.It was also difficult to establish human regulatory dendritic cell specific to antigens for VKH disease.We studied the potential antigen presenting cells in intraocular tissues. There were several kind of cells that can uptake peptide antigens in intraocular tissues. These cells were divided into 3 to 4 groups.These cell groups had different cell surface markers and may play different functions. In the choroidal tissues, these cells may function as APCs stimulating the T cells, while in the retina, these cells may function as APCs regulating the T cells/