Research and development of a therapeutic exercise preconditioning for muscle atrophy and circulatory failure with non-insulin-dependent diabetes mellitus

长期以来，运动训练一直被用作治疗非胰岛素依赖型糖尿病的方法之一。观察了治疗性运动预适应对糖尿病大鼠骨骼肌肌细胞和微循环的影响。预适应包括低强度(有氧)或高强度(无氧)运动，每周分别进行5次60分钟或30分钟的训练，持续3周。与糖尿病大鼠相比，两种治疗的糖尿病大鼠的血糖、糖化血红蛋白和活性氧(ROS)均有所降低，但水平并未完全恢复正常。糖尿病肌肉的毛细血管体积明显减少，即毛细血管回缩。在三块运动训练的糖尿病肌肉中，毛细血管体积增加到对照水平，并完全正常化。总之，本研究的结果为运动训练在减少与糖尿病相关的一些肌肉循环并发症方面的有效性提供了证据。

Exercise training has long been utilized as one of therapy in the non-insulin-dependent diabetes mellitus. The effects of a therapeutic exercise preconditioning on the myocyte and the microcirculation of skeletal muscle in diabetic rats was investigated. The preconditioning consisted of exercise at either low-(aerobic) or Hi-(unaerobic) intensity and included five 60 or 30 min sessions per week for 3 weeks, respectively. Both treated diabetic rats exhibited a decrease in plasma glucose, glycohemoglobin, and reactive oxygen species (ROS) compared with those of the diabetic rats but did not completely normalize levels. The capillary volume in diabetic muscle was significantly less, i.e., capillary regression. In three exercise-trained diabetic muscles, the capillary volumes were increased toward control levels and completely normalize levels. In summary, the results of the present study provide evidence for the effectiveness of exercise training in reducing some of the muscle circulatory complications associated with diabetes mellitus.