Mechanism of increase inphysical activity using a novel animal model of high wheel running

为了解运动改变的机制，我们研究了运动大鼠的神经心理学特征。在SPORTS大鼠海马，细胞外液中去甲肾上腺素（NE）水平升高，而整个组织匀浆中NE水平降低。运动后大鼠海马单胺氧化酶A（MAOA）的蛋白表达和活性水平降低，提示海马MAOA活性降低引起的细胞外NE的升高是运动大鼠运动动机心理调节的神经基础。

To understand mechanisms of modified physical activities, we studied neuropsychological characteristics in SPORTS rat. In the hippocampus of SPORTS rats, the levels of norepinephrine (NE) in the extracellular fluid were increased, whereas those in the whole homogenate of the tissue were decreased. The protein expression and the activity levels of monoamine oxidase A (MAOA) were decreased in the hippocampus of SPORTS rats, suggesting that the elevation of extracellular NE by decreased MAOA activities in hippocampus determine the neural basis of the psychological regulation of exercise motives in the SPORTS rats.