Synthesis of Propellane-Type Heterocycles Using Tandem Cyclization

串联环化反应是一次环化反应开始后的连续的分子内环化反应，是合成有机环化化合物的一种有效的合成方法。在本研究项目中，研究了以醋酸锰为基础的氧化自由基串联环合反应合成新型的螺旋烷型杂环化合物和环芳型大环内酯类化合物。这些化合物的生物活性和物理化学兴趣是可以预料的。

Tandem cyclization is a successive intramolecular cyclization when the cyclization is once started, and important for the synthesis of organic cyclization compounds as an efficient synthetic technique. In the research project, the synthesis of novel propellane-type heterocyclic compounds and cyclophane-type macrolides using manganese (III) acetate-based oxidative radical tandem cyclization was studied. The biological activities and physicochemical interests of these compounds are expected.