Identification of a receptor for the carcinogenic factor secreted from H.pylori, and analysis of its membrane trafficking mechanism

肿瘤坏死因子-α诱导蛋白(TIP-α)是由幽门螺杆菌释放的一种独特的致癌因子。我们发现核仁作为TIPα的受体，将TIPα从细胞表面穿梭到细胞核，导致肿瘤坏死因子-α基因的表达。虽然核仁是一种广为人知的核仁蛋白，但在胃癌细胞表面也存在核仁。因此，表面有核仁素的细胞被认为是TIPα高度易感的细胞，从而导致胃癌的发生。这些结果表明，TIPα与核仁素的相互作用是胃中一种新的致癌机制。

Tumor necrosis factor-α inducing protein (Tipα) is a unique carcinogenic factor released from H.pylori. We found that nucleolin acts as a receptor for Tipα, that it shuttles Tipα from the cell surface to nuclei, resulting in TNF-α gene expression. Although nucleolin is a well-known nucleolar protein, nucleolin is also present on the cell surface of gastric cancer cells. So cells with nucleolin on the surface are thought to be a highly susceptible to Tipα for development of gastric cancer. These results indicate the significance of Tipα interaction with nucleolin as a new carcinogenic mechanism in the stomach.