Development of hybrid kidney for removal of protein-bound anionic uremic toxins

我们利用肾细胞过表达的人有机阴离子转运体构建了杂交肾。我们发现，该系统可以选择性地清除蛋白结合的尿毒症毒素，如硫酸吲哚酚，在慢性肾功能衰竭的动物模型。我们还发现，一些蛋白结合尿毒症毒素直接刺激血管平滑肌细胞在体外增殖。

We developed hybrid kidney with renal cell over-expressed human organic anion transporters. We found that this system can selectively remove protein-bound uremic toxins, such as indoxyl sulfate, in animal model of chronic renal failure. We also found that some protein-bound uremic toxins directly stimulate proliferation of vascular smooth muscle cells in vitro.