Development of local regulation strategy for malignant pleural mesothelioma

恶性胸膜间皮瘤是高度恶性的，然而，有时长期生存的报告。在我们的临床分析中，长期生存的条件是完全切除、手术时间短和PS良好，尽管估计此类患者约占患者的20%。在建立新的局部治疗方法的过程中，观察到II型己糖激酶基因的siRNA干扰抑制间皮瘤细胞的增殖活性。为了建立稳定的基因治疗方法，人们尝试了仙台病毒载体的体外转染。

Malignant pleural mesothelioma is highly malignant, however, sometimes long-term survivor has been reported. In our clinical analysis, the conditions of the long-term survival were complete resection, short operative time and good PS although such patients with the conditions are estimated as approximately 20% of the patients. During establishment of the novel local therapy for the disease, siRNA interference of type II hexokinase gene was observed to suppress proliferative activity of mesothlioma cells. Inorder to establish stable gene therapy, in vitro transfection using Sendai virus vector has been tried.