Positron emission tomographic demonstration of myocardial oxidative metabolism Effects of therapy on, oxidative stress, and cardiac function in Patients With Congestive Heart Failure.

在这项研究中，我们还通过C11-乙酸酯正电子发射断层扫描(PET)检测了β受体阻滞剂和他汀类药物对心脏代谢的影响，以证明慢性心力衰竭患者存在过量的氧化应激。本研究共纳入21例慢性心力衰竭患者。所有患者均接受β受体阻滞剂治疗和C11-乙酸酯正电子发射计算机断层扫描。用11C-乙酸酯的单指数清除率(Kmono)测定治疗前后的氧耗量。用工作代谢指数(WMI)的概念测定心脏效率(CE)。WMI=(每搏量指数)×(收缩压)×(心率)/Kmono。将患者分为两组：治疗后EF改善组和EF恶化组。在基线时没有观察到显著的特征差异。缺血性心肌病的比例和他汀类药物或β受体阻滞剂的使用频率没有变化。血清IL-6、TNF-α和sVCAM-1水平在病情恶化组升高。此外，在这项研究中没有显著变化。

In this study, to demonstrate the excess of oxidative stress in chronic heart failure patients, We also examine the effect of Beta blockers and statins, on cardiac metabolism by the C11-acetate positron emission tomography(PET). Enrolled in this study were 21 patients with chronic heart failure. All patients underwent β-blockers treatment and C11-acetate PET. The oxygen consumption was measured by the monoexponential clearance rate of 11C-acetate (Kmono) for before and after treatment. Cardiac efficiency (CE) was determined using the concept of work metabolic index (WMI). WMI was calculated as WMI=(stroke volume index) ×(systolic blood pressure)× (heart rate)/Kmono. The patients were divided into two groups: improved EF and deteriorated EF by treatment. No significant differences were observed in characteristics at baseline. The ratio of ischemic cardiomyopathy and the frequency of statins or β-blockers,did not change. Serum levels of IL-6, TNF-a and sVCAM-1 were increased in the deteriorated group. Furthermore, no significant changes were in this study.