A study for axon regeneration in the damaged CNS -clarification of inhibitory mechanisms of chondroitin sulfate proteoglycan

我试图从分子水平上阐明为什么轴突不能在受损的脊髓中再生，而脊髓中形成了硫酸软骨素蛋白聚糖（CSPG）的梯度。我使用了一种培养系统，该系统复制了在抑制性CSPG梯度上未能向前迁移的轴突末梢。在这项研究中，我的结论是，调节细胞-基质粘附形成在轴突再生中起着至关重要的作用，通过抑制CSPG梯度。

I attempt to molecularly clarify why axons cannot regenerate in the damaged spinal cord where a gradient of chondroitin sulfate proteoglycan (CSPG) is formed. I used a culture system that reproduced axon endings failing to migrate forward on the inhibitory CSPG gradient. In this study, I conclude that regulation of cell-matrix adhesion formation plays a critical role in axon regeneration across the inhibitory CSPG gradient.