Design of simulated moving bed chromatography based on asynchronous shifts

近年来，连续色谱法在纯化学成分的生产中获得了越来越多的兴趣，特别是在制药工业中。在真实移动床过程的基础上，研究了多塔系统中进口和出口同时移动的模拟移动床过程，并在实践中成功实现。然而，传统的SMB工艺表现出一些缺点，这些缺点可以通过在时间间隔的不同时刻更灵活地改变进口和出口位置来避免。为了找到具有异步移位的SMB的最优过程状态，需要建立基于偏微分方程数值解的详细数学模型，并应用先进的离散数学和整数规划方法。数学模型和解决策略将通过使用部分可用的实验室规模SMB单元执行选定的实验来验证。

In recent years continuous chromatographical processes have attained an increasing interest in the production of pure chemical components in particular in the pharmaceutical industry. Based on the true moving bed process the simulated moving bed (SMB) process with a simultaneous shift of the inlet and outlet points in a multicolumn system has been investigated and successfully implemented in practice. However, the traditional SMB process exhibits several disadvantages which could be avoided by a more flexible regime of shifting the inlet and outlet positions at different moments during the time intervall. To find an optimal process regime for the SMB with asynchronous shift, a detailed mathematical model based on the numerical solution of the underlying partial differential equations and the application of advanced methods of discrete mathematics and integer programming is needed. The mathematical model and solution strategies will be verified by performing selected experiments using a partly available lab scale SMB unit.