The analysis of the dendritic cells in liver is useful for the condition clarification and the earlier detection of the autoimmune hepatitis.

本研究旨在探讨自身免疫性肝炎模型小鼠肝脏树突状细胞比例变化与病情的关系。我们推测这些结果有助于阐明自身免疫性肝炎的早期诊断和潜在机制。肝损伤早期肝内浆细胞样树突状细胞减少。模型小鼠肝脏中活化的常规树突状细胞增多，并产生大量炎性细胞因子。说明肝内浆细胞样树突状细胞对肝损伤的预防是必要的。在这种情况下，小鼠肝脏中的调节性T细胞也增加。肝内浆细胞样树突状细胞与调节性T细胞的联合是预防自身免疫性肝炎的必要条件。提示本研究为自身免疫性肝炎的早期诊断和治疗提供了新的方法。

We examined whether there was relationship between the proportional change of dendritic cells in the liver of model mouse and the condition of the autoimmune hepatitis. We hypothesized that these results were useful for the clarification of the early diagnostics and underlying mechanism of the autoimmune hepatitis. The plasmacytoid dendritic cells in liver decreased at early stage of liver injury. Activated conventional dendritic cells increased with the liver of the model mouse and produced a large amount of inflammatory cytokines. It explained that the intrahepatic plasmacytoid dendritic cells were necessary to prevention of liver damage. In this situation, the regulatory T cell also increased in liver of the mice. The prevention of the autoimmune hepatitis is necessary for the association between intrahepatic plasmacytoid dendritic cells and regulatory T cells. It was suggested that these findings were useful for the early diagnosis of autoimmune hepatitis and the new method of treatment in the future.