Development of carbohydrate-based drug delivery systems

慢性皮肤病影响了5%的人口。治疗具有挑战性和长期性，因为这些疾病是慢性和不可预测的。目前治疗牛皮癣最有效的方法是全身给药。长期使用这些疗法会导致诸如肾或肝损伤等副作用。该建议描述了一种局部治疗牛皮癣的新方法，其中强效药物与透明质酸支架分子相连接，并直接应用于病变组织。这种方法的优点包括通过透明质酸受体过程介导的靶向药物递送和观察到的药物毒性的潜在改善。

Chronic skin disorders affect 5% of the population. Treatment is challenging and long term because these disorders are chronic and unpredictable. Currently the most potent therapies for psoriasis are administered systemically. Long term usage of these therapies causes side effects such as kidney or liver damage. This proposal describes a new approach to the topical treatment of psoriasis where potent drugs are linked to a hyaluronan scaffold molecule and are directly applied to the diseased tissue. Advantages of this approach include targeted drug delivery mediated by hyaluronan receptor processes and potential amelioration of the observed drug toxicities.