Structure-based discovery of anti-parainfluenza viral agents

基于结构的抗副流感病毒药物的发现

• 批准号: DP1094549
• 负责人: Prof Mark von Itzstein
• 金额: $ 35.53万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094549
• 关键词: Structure; based; discovery; anti; parainfluenza

Respiratory diseases, for example croup and bronchitis, in children are caused in the main by human parainfluenza viruses (hPIVs) types 1-3. No vaccines or specific antiviral therapy against hPIV infections exist. This project targets an essential protein in the virus' lifecycle. The essential triple role of the protein in virus spread makes it an attractive target for the development of hPIV-specific drugs. This project aims to produce lead-like compounds that inhibit the protein's function and may provide novel drug candidates for further development. Furthermore the role of human host cell-associated carbohydrates in parainfluenza infection will be better understood.

儿童呼吸道疾病，例如哮吼和支气管炎，主要由1-3型人副流感病毒（hPIV）引起。目前还没有针对hPIV感染的疫苗或特异性抗病毒治疗。 该项目针对病毒生命周期中的一种必需蛋白质。该蛋白在病毒传播中的重要三重作用使其成为开发hPIV特异性药物的有吸引力的靶点。该项目旨在生产抑制蛋白质功能的铅样化合物，并可能为进一步开发提供新的候选药物。 此外，人类宿主细胞相关碳水化合物在副流感病毒感染中的作用将得到更好的理解。