How dose the alteration in mechanical load due to change of alignment influence articular cartilage of knee joint

了解由于关节走向改变而引起的机械载荷变化对膝关节软骨的影响是非常重要的。本研究不能建立膝关节排列改变所致膝关节骨关节炎(OA)的动物模型。然而，我们发现自发性膝骨性关节炎的STR/OrtCrlj小鼠的膝关节骨关节炎改变可能是由胫骨内侧扭转引起的。

It is very important to understand how the alteration in mechanical load due to change of alignment influences articular cartilage of knee joint. In this study we could not establish the animal model that had an onset of osteoarthritis (OA) of knee joint by change of knee alignment. However, we found that OA changes of the patellofemoral joint in STR/OrtCrlj mice that spontaneously developed knee OA may be caused by internal tibial torsion.