Characteristics and new bone formation of coral as an ideal sacaffold

珊瑚的机械强度为12.4 Mpa。珊瑚内部有数不清的管状结构，直径100-300μm，与外界相通，通过气孔与邻近的导管相连。骨骼表面覆盖有数不清的60-200 nm圆形突起。在体外，珊瑚颗粒周围可见毛细血管的形成。在活体实验中，一块珊瑚被植入到狗股骨的一个实验性缺陷中。8周后，珊瑚内可见多核巨细胞与珊瑚接触，珊瑚块内腔内可见骨增大，与成骨细胞交界的新骨形成。

Mechanical strength of coral was 12.4 Mpa. Inside the coral were innumerable tubular structures 100-300 μm in diameter that communicated with the outside, connected to neighboring ducts through pores. The surface of the skeleton was covered with innumerable rounded projections of 60-200 nm were observed. In vitro, formation of capillaries was seen around coral particles. In vivo, a block of coral was implanted into an experimental defect in a canine femur. After 8 weeks, multinucleated giant cells were observed in contact with the coral, and bone augmentation was seen together with new bone formation bordered by osteoblasts in the inner cavities of the coral block.