The Design of New Integrase Inhibitors Targeting HIV-1

目前仍看不到治愈全球艾滋病毒大流行的方法，而日益恶化的病毒耐药性问题促使人们需要寻找新的、新的化合物用于治疗。该项目旨在通过针对艾滋病毒生命周期中的两种不同的酶来设计和合成新的抗艾滋病毒药物。这种设计单个分子支架以靶向不同酶的“双重作用”方法将实现协同效应，同时将开发成本降至最低。这一药物化学项目的预期结果包括发现新的化合物，这些化合物有可能作为艾滋病毒的治疗剂进一步开发。

There is still no cure in sight for the worldwide HIV pandemic and the worsening viral resistance problem creates a need to find new and novel compounds for therapeutic use. This project aims to design and synthesize new anti-HIV drugs by targeting two separate enzymes within the HIV life-cycle. This 'dual-action' approach of designing a single molecular scaffold to target separate enzymes would enable a synergistic effect while minimizing development costs. The expected outcomes from this medicinal chemistry project include the discovery of new compounds with the potential for further development as therapeutic agents against HIV.