Synthetic Studies on Biologically Functional Molecules

为了开发有效的天然产物合成路线，这些天然产物已被用作药物，或有望作为候选药物，我们启动了我们的合成计划。实现了海鞘素743、麦角酸、石杉碱甲、盐孢酰胺等化合物的全合成。在已建立的合成路线的基础上，合成了长春碱、奥司他韦等多种天然产物类似物及相关分子。

Aiming for development of efficient synthetic routes toward natural products, which have been used as drugs, or which are expected as drug candidate, we initiated our synthetic programs. As a result, total synthesis of ecteinascidin 743, lysergic acid, huperzine A, salinosporamide and so on have been achieved. Based on the established synthetic routes, a variety of analogs of natural products and related molecules, which includes vinblastine, oseltamivir and so on have been synthesized.