Development of a centrifugal type mechanical circulatory support device TinyPump for infants and children

TinyPump是一种一次性微型离心血泵，其启动体积为5ml，用于支持婴儿和儿童的血液循环，并在体外和体内研究了其泵的性能、耐久性和生物相容性。TinyPump由一个直径30mm的叶轮组成，该叶轮具有6个直叶片，其中心由流体动力轴承支撑，并通过径向磁耦合扭矩旋转。在3kg新生仔猪的体外循环研究中，TinyPump在血液稀释、溶血和炎症反应方面表现出优异的性能。在10 Kg柴巴山羊的左心室辅助实验中，3只动物的TinyPump显示出持续30天的安全、稳定的循环支持。TinyPump可为婴幼儿提供安全可靠的循环支持。

A disposable, tiny centrifugal blood pump TinyPump having priming volume of 5 ml has been designed to support circulation of infants and children and its pump performance, durability and bio-compatibility were studied in vitro and in vivo. The TinyPump comprises of a 30mm diameter impeller having 6 straight vanes supported with a hydrodynamic bearing at its center and rotated by a radial magnetic coupling torque. In the cardiopulmonary bypass study using 3 Kg newborn piglets, the TinyPump showed superior performances in terms of hemo-dilution, hemolysis, and inflammatory responses. In the left ventricular assist experiments using 10 Kg Shiba-goats, the TinyPump revealed safe, stable circulatory support for the duration of 30 days in 3 animals. The TinyPump can provide safe and reliable circulatory support in the infants and children.