Mechanism of Tumor formation by deregulated circadian rhythm and strategy for its prevention

为了阐明昼夜节律失调是否与癌症的发生有关，用DMBA(7，12-二甲基苯并[a]蒽)处理的4或5日龄小鼠分别在昼夜完全黑暗(Dark and Dark，DD)或12h光照和12h黑暗(Light and Dark，LD)条件下饲养。30周后处死小鼠，进行光谱分析和肿瘤数目分析。处于DD状态的小鼠发生肺癌的几率显著增加(雄性小鼠的肺癌发病率是雄性小鼠的3.9倍，雌性小鼠的肺癌发病率是雌性小鼠的2.1倍)。下一步，昼夜节律失调如何促进肺部肿瘤的分子机制将被阐明。

To clarify whether the deregulation of circadian rhythm is involved in cancer, DMBA (7,12-dimethylbenz[a]anthracene) treated mice of 4 or 5 days old were kept in the completely dark condition during day and night (Dark and Dark, DD) or in 12 h-light and 12 h-dark condition (Light and Dark, LD). After 30 weeks, mice were sacrificed, and the spectrum and the number of tumors were analyzed. Mice kept in DD condition developed significantly more lung tumors (3.9 fold more lung tumors in male mice and 2.1 fold more lung tumors in female mice). As a next step, the molecular mechanisms of how deregulation of circadian rhythm promotes lung tumors will be elucidated.