Molecular basis of the splicing regulators that are related to the diseases.
Molecular basis of the splicing regulators that are related to the diseases.
批准号:
20310141
负责人:
MUTO Yutaka
金额:
$11.73万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
在真核细胞中,前体mRNA剪接反应在生物系统的调节中起着至关重要的作用。在本研究中,我们从结构角度研究了剪接组成型(U1/U2 snRNP)和调节因子(尤其是与DM和FTD相关的因子)的蛋白质-蛋白质和/或蛋白质-RNA相互作用。
英文摘要
In eukaryotic cells, the pre-mRNA splicing reaction plays a crucial role in the regulation of the biological systems. In the present study, we have investigated the protein-protein and/or protein-RNA interactions of the splicing constitutive (U1/U2 snRNP) and the regulatory factors (especially those related to DM and FTD) on the structural point of view.
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eIF4BとeIF4HのRNAに対する結合能の違い
eIF4B 和 eIF4H 之间 RNA 结合能力的差异
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[津田健吾, 鈴木咲良, 桑迫香奈子, 井上真, 白水美香子, 寺田貴帆, 木川隆則, 武藤裕, 菅野純夫, 横山茂之]
通讯作者:
横山茂之
DOI:
10.1093/nar/gkp546
发表时间:
2009-08
期刊:
Nucleic acids research
影响因子:
14.9
作者:
[Tsuda K, Kuwasako K, Takahashi M, Someya T, Inoue M, Terada T, Kobayashi N, Shirouzu M, Kigawa T, Tanaka A, Sugano S, Güntert P, Muto Y, Yokoyama S]
通讯作者:
Yokoyama S
DOI:
10.1002/prot.22246
发表时间:
2009-05-01
期刊:
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
影响因子:
2.9
作者:
[Kurimoto, Kazuki, Kuwasako, Kanako, Yokoyama, Shigeyuki]
通讯作者:
Yokoyama, Shigeyuki
DOI:
10.1021/bi7024723
发表时间:
2008-06-17
期刊:
BIOCHEMISTRY
影响因子:
2.9
作者:
[Kuwasako, Kanako, Takahashi, Mari, Yokoyama, Shigeyuki]
通讯作者:
Yokoyama, Shigeyuki
RNA recognition motif ドメインにおける分子認識の違い
RNA识别基序结构域分子识别的差异
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[津田健吾, et al.]
通讯作者:
et al.
共 23 条
Structural study of the disease-related splicing regulatory factors
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批准号:23370080
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.99万
-
财政年份:2011
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负责人:MUTO Yutaka
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依托单位:
Structural Study on the early stage spliceosomal complex
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批准号:14580620
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2002
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负责人:MUTO Yutaka
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依托单位:
Structural Study on the RNA recognition mechanism by the Drosophila Sex-lethal protein
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批准号:08680648
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:1996
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负责人:MUTO Yutaka
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依托单位: